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The normal developmental series brains in the Yakovlev Collection has been examined to explore the possibility that various brain regions implicated in schizophrenia may show changes in myelination during late adolescence, a period coinciding with the appearance of early symptoms of this disorder. The prefrontal, cingulate, and parahippocampal (entorhinal) cortex, as well as the perforant pathway, cingulum bundle, and hippocampus, were closely examined because these regions have recently been found to show various neuropathological differences in schizophrenia. Observation of these specimens has confirmed earlier reports by Yakovlev and Lecours (1967) that primary motor and sensory cortices show robust myelination early in the first decade of life. In contrast, associative cortical areas show increased amounts of myelin staining only by the second decade, although some cortical areas, like the …