作者
Oghenowede Eyawo, Gwenyth Brockman, Charles H Goldsmith, Mark W Hull, Scott A Lear, Matthew Bennett, Silvia Guillemi, Conrado Franco-Villalobos, Ahmed Adam, Edward J Mills, Julio SG Montaner, Robert S Hogg
发表日期
2019/9/1
期刊
BMJ open
卷号
9
期号
9
页码范围
e025874
出版商
British Medical Journal Publishing Group
简介
Objective
Cardiovascular disease (CVD) is one of the leading non-AIDS-defining causes of death among HIV-positive (HIV+) individuals. However, the evidence surrounding specific components of CVD risk remains inconclusive. We conducted a systematic review and meta-analysis to synthesise the available evidence and establish the risk of myocardial infarction (MI) among HIV+ compared with uninfected individuals. We also examined MI risk within subgroups of HIV+ individuals according to exposure to combination antiretroviral therapy (ART), ART class/regimen, CD4 cell count and plasma viral load (pVL) levels.
Design
Systematic review and meta-analysis.
Data sources
We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews until 18 July 2018. Furthermore, we scanned recent HIV conference abstracts (CROI, IAS/AIDS) and …
学术搜索中的文章
O Eyawo, G Brockman, CH Goldsmith, MW Hull… - BMJ open, 2019