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Genotype and Exercise in LQTS. Background: Repolarization dynamics during exercise in patients with long‐QT Syndrome (LQTS) may be influenced by various factors such as a patient's genotype. We sought to systematically characterize the repolarization dynamics during exercise in patients with LQTS with a particular focus on the influence of genotype.

Methods: Three groups of patients were studied on the basis of clinical status and genotype: LQT1, LQT2, and normal controls. Twenty‐five age‐ and gender‐matched patients were selected for each group. The QTc was measured during bicycle exercise testing and its dynamics were compared between the 3 groups.

Results: The degree of QTc prolongation during exercise was greater in LQTS patients (LQT1 80 ± 47 ms, LQT2 64 ± 41 ms, Control 46 ± 20 ms, P = 0.02), with significant differences between LQT1 and LQT2 patients …