作者
Jason G Andrade, Jean Champagne, Marc Dubuc, Marc W Deyell, Atul Verma, Laurent Macle, Peter Leong-Sit, Paul Novak, Mariano Badra-Verdu, John Sapp, Iqwal Mangat, Clarence Khoo, Christian Steinberg, Matthew T Bennett, Anthony SL Tang, Paul Khairy, CIRCA-DOSE Study Investigators
发表日期
2019/11/26
期刊
Circulation
卷号
140
期号
22
页码范围
1779-1788
出版商
Lippincott Williams & Wilkins
简介
Background
Advanced generation ablation technologies have been developed to achieve more effective pulmonary vein isolation (PVI) and minimize arrhythmia recurrence after atrial fibrillation (AF) ablation.
Methods
We randomly assigned 346 patients with drug-refractory paroxysmal AF to contact force–guided radiofrequency ablation (CF-RF; n=115), 4-minute cryoballoon ablation (Cryo-4; n=115), or 2-minute cryoballoon ablation (Cryo-2; n=116). Follow-up was 12 months. The primary outcome was time to first documented recurrence of symptomatic or asymptomatic atrial tachyarrhythmia (AF, atrial flutter, or atrial tachycardia) between days 91 and 365 after ablation or a repeat ablation procedure at any time. Secondary end points included freedom from symptomatic arrhythmia and AF burden. All patients received an implantable loop recorder.
Results
One-year freedom from atrial tachyarrhythmia defined by …
学术搜索中的文章
JG Andrade, J Champagne, M Dubuc, MW Deyell… - Circulation, 2019