作者
Duncan R Ingrams, Jagdish K Dhingra, Krishnendu Roy, Donald F Perrault Jr, Ian D Bottrill, Sadru Kabani, Elie E Rebeiz, Michail M Pankratov, Stanley M Shapshay, Ramasamy Manoharan, Irving Itzkan, Michael S Feld
发表日期
1997/1
期刊
Head & neck
卷号
19
期号
1
页码范围
27-32
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Background
The fluorescence characteristics of tissues depend upon their biochemical composition and histomorphological architecture, both of which undergo a change during malignant transformation. These changes are detectable as an alteration in the fluorescence spectral profile of the tissues.
Methods
Biopsy specimens from clinically suspicious lesions and normal‐appearing oral mucosa were obtained from patients. Fluorescence spectroscopic measurements were obtained to study the differences between normal and dysplastic tissues and to determine the most appropriate excitation wavelength(s) for exploiting these differences.
Results
Fluorescence spectra from a total of 12 histologically normal (healthy mucosa or benign lesions) and ten abnormal (dysplastic or malignant) tissue samples were compared. Significant spectral differences were seen between the two groups. These differences were …
引用总数
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DR Ingrams, JK Dhingra, K Roy, DF Perrault Jr… - Head & neck, 1997