作者
Brian R Amman, Brian H Bird, Ibrahim A Bakarr, James Bangura, Amy J Schuh, Jonathan Johnny, Tara K Sealy, Immah Conteh, Alusine H Koroma, Ibrahim Foday, Emmanuel Amara, Abdulai A Bangura, Aiah A Gbakima, Alexandre Tremeau-Bravard, Manjunatha Belaganahalli, Jasjeet Dhanota, Andrew Chow, Victoria Ontiveros, Alexandra Gibson, Joseph Turay, Ketan Patel, James Graziano, Camilla Bangura, Emmanuel S Kamanda, Augustus Osborne, Emmanuel Saidu, Jonathan Musa, Doris Bangura, Samuel Maxwell Tom Williams, Richard Wadsworth, Mohamed Turay, Lavalie Edwin, Vanessa Mereweather-Thompson, Dickson Kargbo, Fatmata V Bairoh, Marilyn Kanu, Willie Robert, Victor Lungai, Raoul Emeric Guetiya Wadoum, Moinya Coomber, Osman Kanu, Amara Jambai, Sorie M Kamara, Celine H Taboy, Tushar Singh, Jonna AK Mazet, Stuart T Nichol, Tracey Goldstein, Jonathan S Towner, Aiah Lebbie
发表日期
2020/1/24
期刊
Nature communications
卷号
11
期号
1
页码范围
510
出版商
Nature Publishing Group UK
简介
Marburg virus (MARV) causes sporadic outbreaks of severe Marburg virus disease (MVD). Most MVD outbreaks originated in East Africa and field studies in East Africa, South Africa, Zambia, and Gabon identified the Egyptian rousette bat (ERB; Rousettus aegyptiacus) as a natural reservoir. However, the largest recorded MVD outbreak with the highest case–fatality ratio happened in 2005 in Angola, where direct spillover from bats was not shown. Here, collaborative studies by the Centers for Disease Control and Prevention, Njala University, University of California, Davis USAID-PREDICT, and the University of Makeni identify MARV circulating in ERBs in Sierra Leone. PCR, antibody and virus isolation data from 1755 bats of 42 species shows active MARV infection in approximately 2.5% of ERBs. Phylogenetic analysis identifies MARVs that are similar to the Angola strain. These results provide evidence of MARV …
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BR Amman, BH Bird, IA Bakarr, J Bangura, AJ Schuh… - Nature communications, 2020