作者
Daniel J Park, Gytis Dudas, Shirlee Wohl, Augustine Goba, Shannon LM Whitmer, Kristian G Andersen, Rachel S Sealfon, Jason T Ladner, Jeffrey R Kugelman, Christian B Matranga, Sarah M Winnicki, James Qu, Stephen K Gire, Adrianne Gladden-Young, Simbirie Jalloh, Dolo Nosamiefan, Nathan L Yozwiak, Lina M Moses, Pan-Pan Jiang, Aaron E Lin, Stephen F Schaffner, Brian Bird, Jonathan Towner, Mambu Mamoh, Michael Gbakie, Lansana Kanneh, David Kargbo, James LB Massally, Fatima K Kamara, Edwin Konuwa, Josephine Sellu, Abdul A Jalloh, Ibrahim Mustapha, Momoh Foday, Mohamed Yillah, Bobbie R Erickson, Tara Sealy, Dianna Blau, Christopher Paddock, Aaron Brault, Brian Amman, Jane Basile, Scott Bearden, Jessica Belser, Eric Bergeron, Shelley Campbell, Ayan Chakrabarti, Kimberly Dodd, Mike Flint, Aridth Gibbons, Christin Goodman, John Klena, Laura McMullan, Laura Morgan, Brandy Russell, Johanna Salzer, Angela Sanchez, David Wang, Irwin Jungreis, Christopher Tomkins-Tinch, Andrey Kislyuk, Michael F Lin, Sinead Chapman, Bronwyn MacInnis, Ashley Matthews, James Bochicchio, Lisa E Hensley, Jens H Kuhn, Chad Nusbaum, John S Schieffelin, Bruce W Birren, Marc Forget, Stuart T Nichol, Gustavo F Palacios, Daouda Ndiaye, Christian Happi, Sahr M Gevao, Mohamed A Vandi, Brima Kargbo, Edward C Holmes, Trevor Bedford, Andreas Gnirke, Ute Ströher, Andrew Rambaut, Robert F Garry, Pardis C Sabeti
发表日期
2015/6/18
期刊
Cell
卷号
161
期号
7
页码范围
1516-1526
出版商
Elsevier
简介
The 2013–2015 Ebola virus disease (EVD) epidemic is caused by the Makona variant of Ebola virus (EBOV). Early in the epidemic, genome sequencing provided insights into virus evolution and transmission and offered important information for outbreak response. Here, we analyze sequences from 232 patients sampled over 7 months in Sierra Leone, along with 86 previously released genomes from earlier in the epidemic. We confirm sustained human-to-human transmission within Sierra Leone and find no evidence for import or export of EBOV across national borders after its initial introduction. Using high-depth replicate sequencing, we observe both host-to-host transmission and recurrent emergence of intrahost genetic variants. We trace the increasing impact of purifying selection in suppressing the accumulation of nonsynonymous mutations over time. Finally, we note changes in the mucin-like domain of …
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DJ Park, G Dudas, S Wohl, A Goba, SLM Whitmer… - Cell, 2015