作者
Daniel M Berney, Gabrielle Fisher, Michael W Kattan, R Timothy D Oliver, Henrik Møller, Paul Fearn, James Eastham, Peter Scardino, Jack Cuzick, Victor E Reuter, Christopher S Foster, Trans‐Atlantic Prostate Group
发表日期
2007/12
期刊
BJU international
卷号
100
期号
6
页码范围
1240-1244
出版商
Blackwell Publishing Ltd
简介
OBJECTIVE
To examine data on the changes in the accuracy of the diagnosis of prostate cancer and of Gleason grading in the modern era.
PATIENTS AND METHODS
The study comprised a pathological review within a multicentre study of patients with clinically localized prostate cancer diagnosed in the UK from 1991 to 1996 (inclusive) and treated by watchful‐waiting or hormonal therapy alone. The clinical follow‐up was available, histopathological appearances were reviewed and the Gleason score at diagnosis was compared with the Gleason score as analysed by a panel of genitourinary pathologists using internationally agreed criteria. In all, 1789 patients diagnosed with prostate cancer between 1991 and 1996 were reviewed, with disease‐specific survival as the main outcome measure.
RESULTS
In all, 133 patients (7%) were reassigned a nonmalignant diagnosis. There was a significant …
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DM Berney, G Fisher, MW Kattan, RTD Oliver, H Møller… - BJU international, 2007