作者
Johan WH Verjans, Dagfinn Lovhaug, Navneet Narula, Artiom D Petrov, Bård Indrevoll, Emma Bjurgert, Tatiana B Krasieva, Lizette B Petersen, Grete M Kindberg, Magne Solbakken, Alan Cuthbertson, Mani A Vannan, Chris PM Reutelingsperger, Bruce J Tromberg, Leonard Hofstra, Jagat Narula
发表日期
2008/5
期刊
JACC: Cardiovascular Imaging
卷号
1
期号
3
页码范围
354-362
出版商
American College of Cardiology Foundation
简介
Objectives
The purpose of this study was to evaluate the feasibility of noninvasive imaging of angiotensin II (AT) receptor upregulation in a mouse model of post-myocardial infarction (MI) heart failure (HF).
Background
Circulating AT levels do not reflect the status of upregulation of renin-angiotensin axis in the myocardium, which plays a central role in ventricular remodeling and evolution of HF after MI. Appropriately labeled AT or AT receptor blocking agents should be able to specifically target AT receptors by molecular imaging techniques.
Methods
AT receptor imaging was performed in 29 mice at various time points after permanent coronary artery ligation or in controls using a fluoresceinated angiotensin peptide analog (APA) and radiolabeled losartan. The APA was used in 19 animals for intravital fluorescence microscopy on a beating mouse heart. Tc-99m losartan was used for in vivo radionuclide imaging and …
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JWH Verjans, D Lovhaug, N Narula, AD Petrov… - JACC: Cardiovascular Imaging, 2008