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Context: Insulin resistance and chronic low level inflammation are often present in women with polycystic ovary syndrome (PCOS).

Objective: The purpose of this study was to determine the effects of hyperglycemia on reactive oxygen species (ROS) generation from mononuclear cells (MNCs) in PCOS.

Design: This was a prospective controlled study.

Setting: The study was conducted at an academic medical center.

Patients: The study population consisted of 16 women with PCOS (eight lean, eight obese) and 15 age- and body composition-matched controls (eight lean, seven obese).

Main Outcome Measures: Insulin sensitivity was derived from a 2-h, 75-g oral glucose tolerance test (IS_OGTT). ROS generation and p47^phox protein expression were quantitated from MNCs obtained from blood drawn fasting and 2 h after glucose ingestion …