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Studies have shown that insulin resistance increases with age, independent of changes in total adiposity. However, there is growing evidence that the development of insulin resistance may be more closely related to abdominal adiposity. To evaluate the independent effects of aging and regional and total adiposity on insulin resistance, we performed hyperinsulinemic euglycemic clamps on 17 young (21–33 yr) and 67 older (60–72 yr) men and women. We assessed FFM and total and regional adiposity by hydrodensitometry and anthropometry. Insulin-stimulated GORs at a plasma insulin concentration of ∼450 pM averaged 45.6 ± 3.3 μmol · kg FFM⁻¹ · min⁻¹ (mean ± SE) in the young subjects, 45.6 ± 10.0 μmol · kg FFM⁻¹ · min⁻¹ in 24 older subjects who were insulin sensitive, and 23.9 ± 11.7 μmol · kg FFM⁻¹ · min⁻¹ in 43 older subjects who were insulin resistant. Few significant differences were apparent in …