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Results

Eleven studies (n= 30,146) were included. MetS was significantly associated with the development of eGFR< 60 ml/min per 1.73 m 2 (odds ratio, 1.55; 95% CI, 1.34, 1.80). The strength of this association seemed to increase as the number of components of MetS increased (trend P value= 0.02). In patients with MetS, the odds ratios (95% CI) for development of eGFR< 60 ml/min per 1.73 m 2 for individual components of MetS were: elevated blood pressure 1.61 (1.29, 2.01), elevated triglycerides 1.27 (1.11, 1.46), low HDL cholesterol 1.23 (1.12, 1.36), abdominal obesity 1.19 (1.05, 1.34), and impaired fasting glucose 1.14 (1.03, 1.26). Three studies reported an increased risk for development of microalbuminuria or overt proteinuria with MetS.

Conclusions

MetS and its components are associated with the development of eGFR< 60 ml/min per 1.73 m 2 and microalbuminuria or overt proteinuria.