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1. Comparison of the chemical constituents of geographically diverse collections of six dorid nudibranchs has revealed that those species that are capable of de novo biosynthesis of defensive metabolites always produce the same array of chemicals.

2. Conversely, those species that acquire chemicals from their sponge diet have a variable chemical arsenal.

3. It is proposed that chemical consistency be used as an indicator of the origin of chemicals in the defensive arsenal of dorid nudibranchs.