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Respiratory inflammatory disorders, including asthma and chronic obstructive pulmonary disease, are prevalent conditions affecting the airways. Current study aimed to investigate the impact of famotidine on respiratory inflammation in rats. Thirty adult male albino rats were segmented into five distinct groups, each group comprising six rats (n= 6). A_group (Negative Control) rats received distilled water only, without any drug; B_group (Positive Control) rats underwent ovalbumin sensitization and challenge of the airways; C_group rats were treated orally with a dose of prednisolone (4.12 mg/kg/d) and subjected to ovalbumin sensitization of the airways; D_group rats received oral famotidine at a dose of 20 mg/kg/d with ovalbumin sensitization of the airways; and E_group rats were given oral prednisolone (4.12 mg/kg) and famotidine (20 mg/kg) with ovalbumin sensitization of the airways. The count of inflammatory cells in the broncho-alveolar lavage fluid was determined, as well as lung tissue histological analysis was conducted. The eosinophils, neutrophils, mononuclear cells, and total white blood cell count were all increased (P< 0.05) in the positive control (B_group) when compared to the negative control group. Both D and E_groups, when treated with famotidine, showed a significant reduction (P< 0.05) in the eosinophils, neutrophils, mononuclear cells, and total white blood cell count. Additionally, the histopathological examination revealed that both of these groups showed reduced accumulation of inflammatory cells within the lungs and dilation of the bronchiolar wall across the lung tissue. In conclusion, famotidine has a protective effect …