作者
Karem H Alzoubi Zuhair Bani Ismail Mohamed K AL-Essa Osama Y Alshogran Reem F Abutayeh Nareman Abu-Baker
发表日期
2018/6
期刊
Clinical Pharmacology: Advances and Applications
卷号
10
页码范围
73–78
出版商
Dovepress
简介
Introduction
This study explored D-ribose pharmacokinetics after intravenous (IV) and oral administration to healthy rabbits.
Materials and methods
D-ribose was administered once as 420 mg/kg (N=4) or 840 mg/kg (N=6) dose intravenously, or as an oral dose of 420 mg/kg (N=3) or 840 mg/kg (N=3). Serum was obtained at various time points, up to 210 minutes after administration. Urine was also collected after IV administration. Pharmacokinetic parameters were determined from drug concentration–time data using Kinetica software.
Results
The findings showed that D-ribose follows a dose-dependent kinetic profile. With doubling the IV dose, AUCtotal was significantly increased by threefold, while the clearance was decreased by 44%. The half-life was 1.7-fold longer at the higher dose. Similar nonsignificant trends were also observed at oral administration. D-ribose was rapidly absorbed (Tmax=36–44 minutes) and …
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KH Alzoubi, ZB Ismail, MK Al-Essa, OY Alshogran… - Clinical Pharmacology: Advances and Applications, 2018