作者
Samuel E Jones, Jacqueline M Lane, Andrew R Wood, Vincent T van Hees, Jessica Tyrrell, Robin N Beaumont, Aaron R Jeffries, Hassan S Dashti, Melvyn Hillsdon, Katherine S Ruth, Marcus A Tuke, Hanieh Yaghootkar, Seth A Sharp, Yingjie Jie, William D Thompson, Jamie W Harrison, Amy Dawes, Enda M Byrne, Henning Tiemeier, Karla V Allebrandt, Jack Bowden, David W Ray, Rachel M Freathy, Anna Murray, Diego R Mazzotti, Philip R Gehrman, Debbie A Lawlor, Timothy M Frayling, Martin K Rutter, David A Hinds, Richa Saxena, Michael N Weedon
发表日期
2019/1/29
期刊
Nature communications
卷号
10
期号
1
页码范围
343
出版商
Nature Publishing Group UK
简介
Being a morning person is a behavioural indicator of a person’s underlying circadian rhythm. Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase the number of genetic loci associated with being a morning person from 24 to 351. Using data from 85,760 individuals with activity-monitor derived measures of sleep timing we find that the chronotype loci associate with sleep timing: the mean sleep timing of the 5% of individuals carrying the most morningness alleles is 25 min earlier than the 5% carrying the fewest. The loci are enriched for genes involved in circadian regulation, cAMP, glutamate and insulin signalling pathways, and those expressed in the retina, hindbrain, hypothalamus, and pituitary. Using Mendelian Randomisation, we show that being a morning person is causally associated with better mental health but does not affect BMI or risk of Type 2 diabetes. This study …
学术搜索中的文章
SE Jones, JM Lane, AR Wood, VT van Hees, J Tyrrell… - Nature communications, 2019