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C hi G. and M arcouiller DW Isolating the effect of natural amenities on population change at the local level, Regional Studies. As latent production inputs, natural amenities are thought to serve as the basis for a variety of regional effects. In this study, natural amenity and socio-economic conditions were analysed with respect to population growth empirically estimated at the municipal level in an amenity-rich lakes region of the North Central United States from 1970 to 2000 with a specific focus on spatial relationships. The limited results suggest mixed effects that confirm an increased amenity influence as one of many factors that drive localized population change.