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Hepatitis C virus (HCV), which is a member of the Flaviviridae family, causes human liver disease with an estimated 170 million people being infected worldwide (1). Chronic HCV infections eventually lead to liver cirrhosis and hepatocellular carcinoma (1, 2). The discovery of sofosbuvir, a nucleotide analog inhibitor of the viral RNA-dependent RNA polymerase NS5B, introduced a very potent compound with a high barrier to resistance (3). Unfortunately, no vaccines are available against HCV. The viral genome is approximately 9,600 nucleotides in length and comprises a single open reading frame (ORF) which encodes a~ 3,000 amino acid polyprotein that