作者
Yen Ying Lim, Pawel Kalinowski, Robert H Pietrzak, Simon M Laws, Samantha C Burnham, David Ames, Victor L Villemagne, Christopher J Fowler, Stephanie R Rainey-Smith, Ralph N Martins, Christopher C Rowe, Colin L Masters, Paul T Maruff
发表日期
2018/4/1
期刊
JAMA neurology
卷号
75
期号
4
页码范围
488-494
出版商
American Medical Association
简介
Importance
Older age, high levels of β-amyloid (Aβ), and the presence of the apolipoprotein E (APOE) ε4 allele are risk factors for Alzheimer disease (AD). However, the extent to which increasing age, Aβ, and ε4 are associated with memory decline remains unclear, and the age at which memory decline begins for Aβ-positive ε4 carriers and noncarriers has not been determined.
Objective
To determine the association of age, Aβ level, andAPOEε4 with memory decline in a large group of cognitively healthy older adults.
Design, Setting, and Participants
This longitudinal observational study included cognitively healthy older adults (age >60 years) enrolled in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study from March 31, 2006, through March 31, 2017; of 1583 individuals enrolled, 1136 refused or were excluded owing to other criteria (eg, having mild cognitive impairment or AD). Participants underwent Aβ …
学术搜索中的文章
YY Lim, P Kalinowski, RH Pietrzak, SM Laws… - JAMA neurology, 2018