作者
Michele Albert, Clare M Tempany, Delray Schultz, Ming‐Hui Chen, Robert A Cormack, Sanjaya Kumar, Mark D Hurwitz, Clair Beard, Kemal Tuncali, Michael O'Leary, George P Topulos, Kristin Valentine, Lynn Lopes, Angela Kanan, Daniel Kacher, James Rosato, Hanne Kooy, Ferenc Jolesz, David L Carr‐Locke, Jerome P Richie, Anthony V D'Amico
发表日期
2003/9/1
期刊
Cancer: Interdisciplinary International Journal of the American Cancer Society
卷号
98
期号
5
页码范围
949-954
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
BACKGROUND
This study was designed to estimate the rates of late genitourinary (GU) and rectal toxicity after magnetic resonance image (MRI)‐guided prostate brachytherapy exclusively or in conjunction with external beam radiation therapy (EBRT).
METHODS
Between November 1997 and April 2002, 201 patients with category T1C prostate carcinoma (according to the 2002 American Joint Committee on Cancer staging criteria), prostate specific antigen levels < 10 ng/mL, and biopsy Gleason score 3 + 4 disease were treated with MRI‐guided brachytherapy exclusively or in conjunction with EBRT. The MRI‐guided technique was designed to spare the urethra based on delivery of the prescription dose to the peripheral zone exclusively. The Kaplan–Meier method was used to estimate rates of freedom from late GU and rectal toxicity. Comparisons were made using a log‐rank test.
RESULTS
At a median …
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