作者
Olfa Derbel, Sami Limem, Céline Ségura-Ferlay, Jean-Christophe Lifante, Christian Carrie, Jean-Louis Peix, Françoise Borson-Chazot, Claire Bournaud, Jean-Pierre Droz, Christelle de La Fouchardière
发表日期
2011/12
期刊
BMC cancer
卷号
11
页码范围
1-8
出版商
BioMed Central
简介
Background
Anaplastic thyroid carcinoma (ATC) is among the most aggressive human malignancies. It is associated with a high rate of local recurrence and with poor prognosis.
Methods
We retrospectively reviewed 44 consecutive patients treated between 1996 and 2010 at Leon Berard Cancer Centre, Lyon, France. The combined treatment strategy derived from the one developed at the Institut Gustave Roussy included total thyroidectomy and cervical lymph-node dissection, when feasible, combined with 2 cycles of doxorubicin (60 mg/m2) and cisplatin (100 mg/m2) Q3W, hyperfractionated (1.2 Gy twice daily) radiation to the neck and upper mediastinum (46-50 Gy), and then four cycles of doxorubicin-cisplatin.
Results
Thirty-five patients received the three-phase combined treatment. Complete response after …
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O Derbel, S Limem, C Ségura-Ferlay, JC Lifante… - BMC cancer, 2011