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The advancement in wireless sensor and information technology has offered enormous healthcare opportunities for wearable healthcare devices and has changed the way of health monitoring. Despite the importance of this technology, limited studies have paid attention for predicting individuals’ influential factors for adoption of wearable healthcare devices. The proposed research aimed at determining the key factors which impact an individual′s intention for adopting wearable healthcare devices. The extended technology acceptance model with several external variables was incorporated to propose the research model. A multi‐analytical approach, structural equation modelling‐neural network, was considered for testing the proposed model. The results obtained from the structural equation modelling showed that the initial trust is considered as the most determinant and influencing factor in the decision of …