作者
Kelly Smart, Sylvia ML Cox, Stephanie G Scala, Maria Tippler, Natalia Jaworska, Michel Boivin, Jean R Séguin, Chawki Benkelfat, Marco Leyton
发表日期
2019/5/1
期刊
European journal of nuclear medicine and molecular imaging
卷号
46
页码范围
1179-1183
出版商
Springer Berlin Heidelberg
简介
Purpose
The purpose of this study was to assess, in a large sample of healthy young adults, sex differences in the binding potential of [11C]ABP688, a positron emission tomography (PET) tracer selective for the metabotropic glutamate type 5 (mGlu5) receptor.
Methods
High resolution [11C]ABP688 PET scans were acquired in 74 healthy volunteers (25 male, 49 female, mean age 20 ± 3.0). Mean binding potential (BPND = fND * (Bavail / KD)) values were calculated in the prefrontal cortex, striatum, and limbic regions using the simplified reference tissue model with cerebellar grey matter as the reference region.
Results
[11C]ABP688 BPND was significantly higher in men compared to women in the prefrontal cortex (p < 0.01), striatum (p < 0.001), and hippocampus (p < 0.05). Whole-brain BPND was 17 …
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K Smart, SML Cox, SG Scala, M Tippler, N Jaworska… - European journal of nuclear medicine and molecular …, 2019