作者
Hamed Mohammadi, Sepide Talebi, Abed Ghavami, Masoumeh Rafiei, Shima Sharifi, Zahra Faghihimani, Golnaz Ranjbar, Maryam Miraghajani, Gholamreza Askari
发表日期
2021/12/1
来源
Journal of Trace Elements in Medicine and Biology
卷号
68
页码范围
126857
出版商
Urban & Fischer
简介
Background & Objective
Current evidence is debatable regarding the feasible effects of zinc supplementation on the inflammation and oxidative stress status of adults. This systematic review and meta-analysis aimed to clarify this inconclusiveness.
Materials and Methods
Literature search was conducted via online databases such as PubMed, Scopus, ISI Web of Science, Cochrane Library, and Google Scholar until June 2020. The overall effect was presented as the weighted mean difference (WMD) at 95 % confidence interval (CI) in a random-effects meta-analysis model. Publication bias was also assessed using Egger’s and Begg’s statistics.
Results
In total, 25 clinical trials (n = 1428) were reviewed, which indicated that zinc supplementation significantly affects the concentration of C- reactive protein (WMD: -0.03 mg/l; 95 % CI: -0.06, 0.0; P = 0.029), interlukin-6 (WMD: -3.81 pg/mL; 95 % CI: -6.87, -0.76; P = 0.014 …
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H Mohammadi, S Talebi, A Ghavami, M Rafiei, S Sharifi… - Journal of Trace Elements in Medicine and Biology, 2021