作者
Mina Djalali, Sepide Talebi, Ehsan Djalali, Mina Abdolahi, Nikolaj Travica, Mahmoud Djalali
发表日期
2023/9/3
期刊
Immunopharmacology and Immunotoxicology
卷号
45
期号
5
页码范围
565-570
出版商
Taylor & Francis
简介
Objective
Imbalances in immune regulation are important features of migraine pathophysiology. In line with this, the current study investigated the efficacy of omega-3 fatty acids supplementation on inflammatory and anti-inflammatory markers in patients with migraines.
Materials and Methods
This randomized, double-blind, placebo-controlled trial consisted of 40 patients that were prone to experiencing episodic migraines. For two months, participants were randomized into one group that received omega-3 supplementation (n= 20), 600 mg of EPA and 300 mg of DHA, twice daily) or another group that received a placebo (n= 20). Transforming growth factor β (TGF-β), interleukin (IL)-4, interferon-gamma (IFN-γ), and interleukin (IL)-17 serum levels were assessed using enzyme-linked immunosorbent assay methods at baseline and following the intervention. The current study was registered on ClinicalTrials.gov with …
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M Djalali, S Talebi, E Djalali, M Abdolahi, N Travica… - Immunopharmacology and Immunotoxicology, 2023