作者
George I Papakostas, Richard C Shelton, John M Zajecka, Bijan Etemad, Karl Rickels, Alisabet Clain, Lee Baer, Elizabeth D Dalton, Garret R Sacco, David Schoenfeld, Michael Pencina, Allison Meisner, Teodoro Bottiglieri, Erik Nelson, David Mischoulon, Jonathan E Alpert, James G Barbee, Sidney Zisook, Maurizio Fava
发表日期
2012/12
期刊
American Journal of Psychiatry
卷号
169
期号
12
页码范围
1267-1274
出版商
American Psychiatric Association
简介
Objective
The authors conducted two multicenter sequential parallel comparison design trials to investigate the effect of l-methylfolate augmentation in the treatment of major depressive disorder in patients who had a partial response or no response to selective serotonin reuptake inhibitors (SSRIs).
Method
In the first trial, 148 outpatients with SSRI-resistant major depressive disorder were enrolled in a 60-day study divided into two 30-day periods. Patients were randomly assigned, in a 2:3:3 ratio, to receive l-methylfolate for 60 days (7.5 mg/day for 30 days followed by 15 mg/day for 30 days), placebo for 30 days followed by l-methylfolate (7.5 mg/day) for 30 days, or placebo for 60 days. SSRI dosages were kept constant throughout the study. In the second trial, with 75 patients, the design was identical to the first, except that the l-methylfolate dosage was 15 mg/day during both 30-day periods.
Results
In the first trial, no …
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GI Papakostas, RC Shelton, JM Zajecka, B Etemad… - American Journal of Psychiatry, 2012