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Myeloid derived suppressor cells (MDSCs) compromised heterogeneous immature myeloid cells, which are activated under pathological conditions, such as cancer, infection, sepsis. MDSCs have suppressive activities on tumor escape immune response. There is no published research regarding to MDSCs in veterinary medicine. Some studies revealed that there is a decreased antitumor immune response among cancer metastatic dogs. We hypothesize that tumor will change circulating MDSCs. By using flow cytometry, this study compares differences in leukocyte expressions of CD11b, a positive marker for MDSCs in mice and human, common leukocyte marker CD45 and neutrophils specific antibody (NSA) expressions between healthy dogs and benign-and malignant-tumor bearing dogs. Taken together, we supposed that our target cells of malignant tumor bearing dogs express medium or decreased intensity in CD45, medium intensity in CD11b and NSA. Follow the path; we can further identify the canine MDSCs which impact the tumor growth in future.