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Background: In humans, type 1 diabetes (T1D) is associated with arterial stiffening as assessed by carotid-femoral pulse wave velocity (cfPWV)[1]. To experimentally study the underlying mechanism of this stiffening, we investigated blood pressure (BP) and cfPWV in streptozotocin (STZ)-induced diabetes in mice. Methods: Twenty-four 9-week-old male C57BL/6 J mice were divided equally among diabetic (induced through once-daily 50 mg/kg STZ injections for five days) and control (sham injections using citrate buffer) groups, and were kept to an age of 24 weeks. Fasting glucose was measured every 4-5 weeks via tail blood collection with levels of 15 mmol/L and higher considered diabetic. Non-invasive tonometric cfPWV was measured in anaesthetised animals (1% isoflurane) 24 h prior to euthanasia; tail-cuff BP was measured directly prior to euthanasia. Results: Diabetic mice exhibited higher fasting glucose …