查看文章

Objective:

Invasive foot-to-foot pulse wave velocity (PWV) is the reference standard for validating new non-invasive PWV-measuring devices. Because of acute haemodynamic variability and data processing issues, PWV shows beat-to-beat variability, which may have important clinical and technical implications. Though current device validation guidelines suggest averaging over at least n= 3 heartbeats to cope with variability, quantitative data on PWV's beat-to-beat variability is lacking. We aimed to quantify this variability and its impact on the confidence of the PWV estimate.

Design and method:

Pressure waveforms were acquired in n= 82 individuals in the ascending aorta and iliac bifurcation using a dual-tip intra-aortic catheter. For each individual, two datasets were recorded: 1) simultaneous ascending and iliac pressure acquisitions (with ECG), and 2) an additional ascending aorta pressure acquisition (with …