查看文章

Objective:

Variability of carotid pulse wave velocity (CFPWV) measurements may be related to measurement errors, but also to physiological beat-to-beat variations in pulse transit time (TT). We aimed to 1) evaluate beat-to-beat variability of CFPWV on simultaneous non-invasive carotid and femoral waveforms without signal artefacts, and 2) explore its clinical and hemodynamic determinants.

Design and method:

In 44 adult patients (47±18 years; 50% men; 32% hypertensive, 27% with chronic kidney disease, 9% diabetic and 5% with cardiovascular disease), three 10 seconds-long acquisitions of carotid and femoral pressure waveforms were performed using Complior Analyse. Raw data of the three recordings were extracted, checked to be artefact-free, concatenated, and subjected to a custom 2nd derivative-based foot detection algorithm. Mean, beat-to-beat standard deviation (SD), and coefficient of variation (CV …