作者
Qiong Chen, Tongzhang Zheng, Qing Lan, Catherine Lerro, Nan Zhao, Qin Qin, Xiaobin Hu, Huang Huang, Jiaxin Liang, Theodore Holford, Brian Leaderer, Peter Boyle, Stephen J Chanock, Nathaniel Rothman, Yawei Zhang
发表日期
2013/7/1
期刊
Cancer epidemiology, biomarkers & prevention
卷号
22
期号
7
页码范围
1332-1335
出版商
American Association for Cancer Research
简介
Background: Chemokines play a pivotal role in immune regulation and response, and previous studies suggest an association between immune deficiency and non-Hodgkin lymphoma (NHL).
Methods: We evaluated the association between NHL and polymorphisms in 18 genes (CCL1, CCL2, CCL5, CCL7, CCL8, CCL11, CCL13, CCL18, CCL20, CCL24, CCL26, CCR1, CCR3, CCR4, CCR6, CCR7, CCR8, and CCR9) encoding for the CC chemokines using data from a population-based case–control study of NHL conducted in Connecticut women.
Results:CCR8 was associated with diffuse large B-cell lymphoma (DLBCL; P = 0.012), and CCL13 was associated with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL; P = 0.003) at gene level. After adjustment for multiple comparisons, none of the genes or single-nucleotide polymorphisms (SNP) were associated with risk of overall NHL or …
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Q Chen, T Zheng, Q Lan, C Lerro, N Zhao, Q Qin, X Hu… - Cancer epidemiology, biomarkers & prevention, 2013