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Dyslipidemia is a condition in which the lipid levels are altered in the body. The fixed oils (FOs) from spices, Alpinia galanga, Cinnamomum zeylanicum, Trigonella foenum-graecum, Foeniculum vulgare, and Myristica fragrans were evaluated as potential sources of anti-dyslipidemic activity. The nutraceutical compound fractions such as polyphenols, tocopherols, γ-oryzanol, and phytosterols were extracted from spice FOs, tested individually and in combination for cytotoxicity and their effect on lipid accumulation in 3T3-L1 and Hep-G2 cell lines. Further, the best performing FOs in the in vitro studies were fed to high fat diet-induced dyslipidemic C57BL/6 mice and studied its activity in the liver and adipose tissue. The in vitro assays showed no cytotoxicity in the studied FOs up to 200 μg/mL concentration. Out of all the studied nutraceutical compound fractions, the γ-oryzanol and phytosterols fractions showed a …