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The antimicrobial activity of Sabulun salo; a local traditional medicated soap widely used by different tribes in Nigeria such as Hausa, Yoruba and Nupe against skin infections was examined against some clinical isolates of pathogenic microorganisms (Staphylococcus aureus, Escherichia coli and Candida albicans) using agar dilution method. The pattern of inhibition varied with the soap concentration and the organisms tested. The soap was more effective on S. aureus with maximum zone of growth inhibition of 28 mm at 100% w/v followed by C. albicans (24mm). However, E. coli was resistant to the soap at all concentrations tested. The minimum inhibitory concentration (MIC) was found to be 12.5% w/v for both S. aureus and C. albicans. The antibacterial activities exhibited by sabulun salo in this study could be attributed to the presence of its constituents which signifies the potential of the soap as a of topical therapeutic agent. These findings therefore, justify the traditional medicinal use of sabulun salo.