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ALTHOUGH angiotensin, potassium, sodium, and adrenocorticotrophic hormone are generally acknowledged as major direct influences on aldosterone secretion, there is a strong case for the existence of other factors which affect aldosterone secretion and which may play physiological roles (see Coghlan et al., 1979, for review). The plasma aldosterone response to metoclopramide (a dopamine antagonist) initially reported by Norbiato et al.(1977) is independent of known aldosterone-controlling factors and suggests the existence of a novel aldosterone-regulating mechanism. The proposition that aldosterone production may be subject to dopaminergic inhibition was originally suggested by Eldwards et al.(1975) and received support from the in vitro studies of McKenna et al.(1979). Recently, Carey et al.(1979; 1980) and Noth et al.(1980) have postulated aldosterone secretion to be under maximal tonic …