作者
AA Elzagallaai, G Koren, JR Bend, MJ Rieder
发表日期
2011/9
来源
Clinical Pharmacology & Therapeutics
卷号
90
期号
3
页码范围
455-460
简介
Drug hypersensitivity reactions (DHRs) are uncommon but potentially fatal adverse events. Their diagnosis and prediction are difficult given their variable presentation and the overlap of symptoms with those of other clinical conditions. Systemic rechallenge is considered the gold standard for the diagnosis of DHRs; however, this may have severe consequences. In vitro tests are currently not sufficiently reliable to provide the basis for clinical decisions. This article summarizes the challenges associated with in vitro testing for DHRs.
Clinical Pharmacology & Therapeutics (2011) 90 3, 455–460. doi:10.1038/clpt.2011.155
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AA Elzagallaai, G Koren, JR Bend, MJ Rieder - Clinical Pharmacology & Therapeutics, 2011