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Clinical isolates (n = 55) of Pseudomonas aeruginosa were screened for the extended spectrum β‐lactamases and metallo‐β‐lactamases activities and biofilm forming capability. The aim of the study was to demonstrate the antibiofilm efficacy of gum arabic capped‐silver nanoparticles (GA‐AgNPs) against the multi‐drug resistant (MDR) biofilm forming P. aeruginosa. The GA‐AgNPs were characterized by UV‐spectroscopy, X‐ray diffraction, and high resolution‐transmission electron microscopy analysis. The isolates were screened for their biofilm forming ability, using the Congo red agar, tube method and tissue culture plate assays. The biofilm forming ability was further validated and its inhibition by GA‐AgNPs was demonstrated by performing the scanning electron microscopy (SEM) and confocal laser scanning microscopy. SEM analysis of GA‐AgNPs treated bacteria revealed severely deformed and …