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To date very little studies are available in the literature on the interaction of Al₂O₃ nanoparticles with multidrug-resistant strains of Staphylococcus aureus. Considering the paucity of earlier reports the objective of present study was to investigate the antibacterial activity of Al₂O₃ NPs (<50 nm) against methicillin-resistant S. aureus and methicillin-resistant coagulase negative staphylococci by various methods. Al₂O₃ NPs were characterized by scanning electron microscopy, high-resolution transmission electron microscopy, and X-ray diffraction. The MIC was found to be in the range of 1,700–3,400 μg/ml. Almost no growth was observed at 2,000 μg/ml for up to 10 h. SEM micrograph revealed that the treated cells were significantly damaged, showed indentation on cell surface and clusters of NPs on bacterial cell wall. HR-TEM micrograph shows disruption and disorganization of cell membrane …