作者
Ronni AG da Silva, Irina Afonina, Kimberly A Kline
发表日期
2021/10/1
来源
Current Opinion in Microbiology
卷号
63
页码范围
117-125
出版商
Elsevier Current Trends
简介
Highlights
- Biofilm infections are heterogenous, persistent and recalcitrant.
- The rise of antibiotic resistance necessitates new therapeutic strategies to eradicate biofilms.
- The diverse nature of biofilm infections will likely require multipronged solutions.
Biofilm formation is a multifactorial process and often a multi-species endeavour that involves complex signalling networks, chemical gradients, bacterial adhesion, and production or acquisition of matrix components. Antibiotics remain the main choice when treating bacterial biofilm-associated infections despite their intrinsic tolerance to antimicrobials, and propensity for acquisition and rapid dissemination of antimicrobial resistance within the biofilm. Eliminating hard to treat biofilm-associated infections that are antibiotic resistant will demand a holistic and multi-faceted approach, targeting multiple stages of biofilm formation, many of which are already in development. This …
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RAG da Silva, I Afonina, KA Kline - Current Opinion in Microbiology, 2021