作者
HaiGwo Hwu, YuanChing Wu, Sandy FC Lee, LingLing Yeh, ShiChin Gwo, HeyChi Hsu, ChingJui Chang, Wei J Chen
发表日期
1997/2/21
期刊
American journal of medical genetics
卷号
74
期号
1
页码范围
1-6
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Positive and negative symptom (NGS) dimensions were examined for their concordance in 46 coaffected schizophrenic sibpairs. Results showed that the symptom dimensions of negative symptoms (NGS), delusionhallucination (DHS), and thought disorganization (TDS) could be formulated. Discrete genetic endowment of these three symptom dimensions was not found as shown by the low concordance in sib pair analysis (kappa = 0.20–0.30). Thirtyseven pairs (80.4%) and 21 pairs (45.7%) had liability, defined by the presence of NGS in any one member of the coaffected sibpairs, of NGS of “any degree,” and of “severe degree” in 46 sibpairs, respectively. Both groups had high prevalence (59.1–81.0%) of positive symptoms. Another 9 (19.6%) and 25 (54.3%) pairs had no liability of NGS of “any degree” or of “severe degree” out of 46 sibpairs, respectively. These two groups had high concordance (kappa …
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HG Hwu, YC Wu, SFC Lee, LL Yeh, SC Gwo, HC Hsu… - American journal of medical genetics, 1997