查看文章

Acute olfactory dysfunction (OD) is a well-documented symptom of coronavirus disease 2019 (COVID-19), yet risk factors for persistent OD remain poorly characterized, making it difficult to optimize clinical management. Prior studies addressing risk factors for persistent COVID-19 OD are limited by subjective OD measurements, delayed olfactory evaluation, or are specific to inpatient subjects. 1–3 In this longitudinal, multicenter, prospective assessment of the natural course of OD among polymerase chain reaction (PCR)-confirmed COVID-19 outpatient subjects, we aimed to determine the clinical risk factors, severity, and specific odorants associated with persistent OD. Sixty-seven PCR-positive ambulatory COVID-19 subjects were prospectively recruited from the UC San Diego Health System and the Barts Health NHS Trust and underwent olfactory evaluation using the 12-item Brief Smell Identification Test (BSIT …