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3. Proper patient positioning, immobilization, and sedation improve access to and decrease movement of target lesions. 4. Precise needle alignment in the chest wall helps reduce manipulation of the needle within the pulmonary parenchyma. 5. Core needle biopsy can improve diagnostic yield without an increase in complication rate.

Since the first report of CT-guided percutaneous needle biopsy in 1976 [1], there has been significant improvement in CT technology and refinement of equipment available to interventional radiologists. With high diagnostic accuracy, sensitivity, and specificity for detection of malignancy [2–5](Table 1), percutaneous needle biopsy of the lung is now an indispensable tool in the evaluation of pulmonary abnormalities. Careful preprocedural evaluation and planning and precise technique are required to achieve the highest possible success rate.