作者
Kim L Bennell, Kade L Paterson, Ben R Metcalf, Vicky Duong, Jillian Eyles, Jessica Kasza, Yuanyuan Wang, Flavia Cicuttini, Rachelle Buchbinder, Andrew Forbes, Anthony Harris, P Yu Shirley, David Connell, James Linklater, Bing Hui Wang, Win Min Oo, David J Hunter
发表日期
2021/11/23
期刊
Jama
卷号
326
期号
20
出版商
American Medical Association
简介
Importance
Most clinical guidelines do not recommend platelet-rich plasma (PRP) for knee osteoarthritis (OA) because of lack of high-quality evidence on efficacy for symptoms and joint structure, but the guidelines emphasize the need for rigorous studies. Despite this, use of PRP in knee OA is increasing.
Objective
To evaluate the effects of intra-articular PRP injections on symptoms and joint structure in patients with symptomatic mild to moderate radiographic medial knee OA.
Design, Setting, and Participants
This randomized, 2-group, placebo-controlled, participant-, injector-, and assessor-blinded clinical trial enrolled community-based participants (n = 288) aged 50 years or older with symptomatic medial knee OA (Kellgren and Lawrence grade 2 or 3) in Sydney and Melbourne, Australia, from August 24, 2017, to July 5, 2019. The 12-month follow-up was completed on July 22, 2020.
Interventions
Interventions …
学术搜索中的文章
KL Bennell, KL Paterson, BR Metcalf, V Duong, J Eyles… - Jama, 2021