作者
Anand Srivastava, Shailja Singh, Shikha Dhawan, M Mahmood Alam, Asif Mohmmed, Chetan E Chitnis
发表日期
2010/11/30
期刊
Molecular and biochemical parasitology
卷号
174
期号
1
页码范围
66-69
出版商
Elsevier
简介
Plasmodium falciparum belongs to the Apicomplexan group of parasites and is characterised by presence of specialized secretory organelles at the apical end. These apical organelles, referred to as microneme and rhoptries, contain proteins that play important roles during host cell invasion by mediating specific functions such as initial attachment, apical reorientation and junction formation. Recently, a protein referred to as P. falciparum apical sushi protein (PfASP), which is expressed at late schizont stage, was localized to micronemes of P. falciparum merozoites. In the present study, we have used indirect immunofluorescence assays and immunoelectron microscopy to demonstrate that PfASP is localized in the neck of rhoptries and not in micronemes as previously described.
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A Srivastava, S Singh, S Dhawan, MM Alam… - Molecular and biochemical parasitology, 2010