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The authors assessed life events during the 12 months before the onset of panic disorder in 64 patients. Compared with a control group of 78 healthy subjects, patients with panic disorder had higher scores however life events were assessed, ie, number of events, weighted normative scores, contextual scores, and number of subjects with major events. Independent life events (those beyond the subject's control) were also more numerous and more severe among the patients. The larger number of events experienced by the patients was due to the more frequent occurrence of life stress in the month before the onset of panic disorder. Loss events had the strongest relationship to panic disorder.