作者
Mike A Nalls, Cornelis Blauwendraat, Costanza L Vallerga, Karl Heilbron, Sara Bandres-Ciga, Diana Chang, Manuela Tan, Demis A Kia, Alastair J Noyce, Angli Xue, Jose Bras, Emily Young, Rainer von Coelln, Javier Simón-Sánchez, Claudia Schulte, Manu Sharma, Lynne Krohn, Lasse Pihlstrøm, Ari Siitonen, Hirotaka Iwaki, Hampton Leonard, Faraz Faghri, J Raphael Gibbs, Dena G Hernandez, Sonja W Scholz, Juan A Botia, Maria Martinez, Jean-Christophe Corvol, Suzanne Lesage, Joseph Jankovic, Lisa M Shulman, Margaret Sutherland, Pentti Tienari, Kari Majamaa, Mathias Toft, Ole A Andreassen, Tushar Bangale, Alexis Brice, Jian Yang, Ziv Gan-Or, Thomas Gasser, Peter Heutink, Joshua M Shulman, Nicholas W Wood, David A Hinds, John A Hardy, Huw R Morris, Jacob Gratten, Peter M Visscher, Robert R Graham, Andrew B Singleton, Astrid D Adarmes-Gómez, Miquel Aguilar, Akbota Aitkulova, Vadim Akhmetzhanov, Roy N Alcalay, Ignacio Alvarez, Victoria Alvarez, Francisco Javier Barrero, Jesús Alberto Bergareche Yarza, Inmaculada Bernal-Bernal, Kimberley Billingsley, Marta Blazquez, Marta Bonilla-Toribio, Juan A Botía, María Teresa Boungiorno, Kathrin Brockmann, Vivien Bubb, Dolores Buiza-Rueda, Ana Cámara, Fátima Carrillo, Mario Carrión-Claro, Debora Cerdan, Viorica Chelban, Jordi Clarimón, Carl Clarke, Yaroslau Compta, Mark R Cookson, David W Craig, Fabrice Danjou, Monica Diez-Fairen, Oriol Dols-Icardo, Jacinto Duarte, Raquel Duran, Francisco Escamilla-Sevilla, Valentina Escott-Price, Mario Ezquerra, Cici Feliz, Manel Fernández, Rubén Fernández-Santiago, Steven Finkbeiner, Thomas Foltynie, Ciara Garcia, Pedro García-Ruiz, Maria Jose Gomez Heredia, Pilar Gómez-Garre, Manuel Menéndez González, Isabel Gonzalez-Aramburu, Sebastian Guelfi, Rita Guerreiro, John Hardy, Sharon Hassin-Baer, Janet Hoenicka, Peter Holmans, Henry Houlden, Jon Infante, Silvia Jesús, Adriano Jimenez-Escrig, Gulnaz Kaishybayeva, Rauan Kaiyrzhanov, Altynay Karimova, Kerri J Kinghorn, Sulev Koks, Jaime Kulisevsky, Miguel A Labrador-Espinosa, Hampton L Leonard, Patrick Lewis, Jose Luis Lopez-Sendon, Ruth Lovering, Steven Lubbe, Codrin Lungu, Daniel Macias, Claudia Manzoni, Juan Marín, Johan Marinus, Maria Jose Marti, Irene Martínez Torres, Juan Carlos Martínez-Castrillo, Marina Mata, Niccolo E Mencacci, Carlota Méndez-del-Barrio, Ben Middlehurst, Adolfo Mínguez, Pablo Mir, Kin Y Mok, Esteban Muñoz, Derek Narendra, Oluwadamilola O Ojo, Njideka U Okubadejo, Ana Gorostidi Pagola, Pau Pastor, Francisco Perez Errazquin, Teresa Periñán-Tocino, Lasse Pihlstrom, Helene Plun-Favreau, John Quinn, Lea R'Bibo, Xylena Reed, Elisabet Mondragon Rezola, Mie Rizig
发表日期
2019/12/1
期刊
The Lancet Neurology
卷号
18
期号
12
页码范围
1091-1102
出版商
Elsevier
简介
Background
Genome-wide association studies (GWAS) in Parkinson's disease have increased the scope of biological knowledge about the disease over the past decade. We aimed to use the largest aggregate of GWAS data to identify novel risk loci and gain further insight into the causes of Parkinson's disease.
Methods
We did a meta-analysis of 17 datasets from Parkinson's disease GWAS available from European ancestry samples to nominate novel loci for disease risk. These datasets incorporated all available data. We then used these data to estimate heritable risk and develop predictive models of this heritability. We also used large gene expression and methylation resources to examine possible functional consequences as well as tissue, cell type, and biological pathway enrichments for the identified risk factors. Additionally, we examined shared genetic risk between Parkinson's disease and other …
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MA Nalls, C Blauwendraat, CL Vallerga, K Heilbron… - The Lancet Neurology, 2019