作者
Bryce Van De Geijn, Graham McVicker, Yoav Gilad, Jonathan K Pritchard
发表日期
2015/11
期刊
Nature methods
卷号
12
期号
11
页码范围
1061-1063
出版商
Nature Publishing Group US
简介
Allele-specific sequencing reads provide a powerful signal for identifying molecular quantitative trait loci (QTLs), but they are challenging to analyze and are prone to technical artifacts. Here we describe WASP, a suite of tools for unbiased allele-specific read mapping and discovery of molecular QTLs. Using simulated reads, RNA-seq reads and chromatin immunoprecipitation sequencing (ChIP-seq) reads, we demonstrate that WASP has a low error rate and is far more powerful than existing QTL-mapping approaches.
学术搜索中的文章
B Van De Geijn, G McVicker, Y Gilad, JK Pritchard - Nature methods, 2015