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In older men an optimal plasma testosterone is associated with reduced all-cause mortality and higher dihydrotestosterone with reduced ischemic heart disease mortality, while …

作者

Bu B Yeap, Helman Alfonso, SA Paul Chubb, David J Handelsman, Graeme J Hankey, Osvaldo P Almeida, Jonathan Golledge, Paul E Norman, Leon Flicker

发表日期

2014/1/1

期刊

The Journal of Clinical Endocrinology & Metabolism

卷号

期号

页码范围

E9-E18

出版商

Oxford University Press

简介

Context

Testosterone (T) levels decline with age and lower T has been associated with increased mortality in aging men. However, the associations of its metabolites, dihydrotestosterone (DHT) and estradiol (E₂), with mortality are poorly defined.

Objective

We assessed associations of T, DHT, and E₂ with all-cause and ischemic heart disease (IHD) mortality in older men.

Participants

Participants were community-dwelling men aged 70 to 89 years who were residing in Perth, Western Australia.

Main Outcome Measures

Plasma total T, DHT, and E₂ were assayed using liquid chromatography-tandem mass spectrometry in early morning samples collected in 2001 to 2004 from 3690 men. Deaths to December 2010 were ascertained by data linkage.

Results

There were 974 deaths (26.4%), including 325 of IHD. Men who …

引用总数

被引用次数：226

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In older men an optimal plasma testosterone is associated with reduced all-cause mortality and higher dihydrotestosterone with reduced ischemic heart disease mortality, while estradiol levels do not predict mortality

BB Yeap, H Alfonso, SAP Chubb, DJ Handelsman… - The Journal of Clinical Endocrinology & Metabolism, 2014

被引用次数：226 相关文章所有 12 个版本