作者
Sriramya Gade, Maheshwari Rajamanikyam, Varahalarao Vadlapudi, Krishna Madhav Nukala, Rajendar Aluvala, Chandrasekhar Giddigari, Naga Jyothi Karanam, Nabin C Barua, Richa Pandey, Vijaya Saradhi V Upadhyayula, Prabhakar Sripadi, Ramars Amanchy, Suryanarayana Murty Upadhyayula
发表日期
2017/3/1
期刊
Biochimica et Biophysica Acta (BBA)-General Subjects
卷号
1861
期号
3
页码范围
541-550
出版商
Elsevier
简介
Background
Chromolaena odorata, has been traditionally known for its insect repellent property. Aim of this study was to determine larvicidal tendency of C. odorata on Culex quinquefasciatus and isolate compounds responsible for this activity and to determine the mechanism of action of these compounds.
Methods
C. odorata plant extract was screened for mosquito larvicidal activity. The extract was fractionated using chromatography and the bioactive fraction showing larvicidal activity was identified. The chemical nature of the compounds in the bioactive fraction was determined using NMR and Mass spectrometry.
Results
We identified phytosterols and alkanols to be the compounds regulating larvicidal activity in the bioactive fraction of the plant extract. Stigmasterol and 1-hexacosanol were identified to be the chief orchestrators of larvicidal activity and their mode of action has been observed to be neurotoxicity. At a …
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S Gade, M Rajamanikyam, V Vadlapudi, KM Nukala… - Biochimica et Biophysica Acta (BBA)-General Subjects, 2017