作者
Caleb J Kelly, Leon Zheng, Eric L Campbell, Bejan Saeedi, Carsten C Scholz, Amanda J Bayless, Kelly E Wilson, Louise E Glover, Douglas J Kominsky, Aaron Magnuson, Tiffany L Weir, Stefan F Ehrentraut, Christina Pickel, Kristine A Kuhn, Jordi M Lanis, Vu Nguyen, Cormac T Taylor, Sean P Colgan
发表日期
2015/5/13
期刊
Cell host & microbe
卷号
17
期号
5
页码范围
662-671
出版商
Elsevier
简介
Interactions between the microbiota and distal gut are fundamental determinants of human health. Such interactions are concentrated at the colonic mucosa and provide energy for the host epithelium through the production of the short-chain fatty acid butyrate. We sought to determine the role of epithelial butyrate metabolism in establishing the austere oxygenation profile of the distal gut. Bacteria-derived butyrate affects epithelial O2 consumption and results in stabilization of hypoxia-inducible factor (HIF), a transcription factor coordinating barrier protection. Antibiotic-mediated depletion of the microbiota reduces colonic butyrate and HIF expression, both of which are restored by butyrate supplementation. Additionally, germ-free mice exhibit diminished retention of O2-sensitive dyes and decreased stabilized HIF. Furthermore, the influences of butyrate are lost in cells lacking HIF, thus linking butyrate metabolism to …
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CJ Kelly, L Zheng, EL Campbell, B Saeedi, CC Scholz… - Cell host & microbe, 2015