作者
Leon Zheng, Caleb J Kelly, Sean P Colgan
发表日期
2015/9/15
来源
American Journal of Physiology-Cell Physiology
卷号
309
期号
6
页码范围
C350-C360
出版商
American Physiological Society
简介
In recent years, the intestinal mucosa has proven to be an intriguing organ to study tissue oxygenation. The highly vascularized lamina propria juxtaposed to an anaerobic lumen containing trillions of metabolically active microbes results in one of the most austere tissue microenvironments in the body. Studies to date have determined that a healthy mucosa contains a steep oxygen gradient along the length of the intestine and from the lumen to the serosa. Advances in technology have allowed multiple independent measures and indicate that, in the healthy mucosa of the small and large intestine, the lumen-apposed epithelia experience Po2 conditions of <10 mmHg, so-called physiologic hypoxia. This unique physiology results from a combination of factors, including countercurrent exchange blood flow, fluctuating oxygen demands, epithelial metabolism, and oxygen diffusion into the lumen. Such conditions result …
学术搜索中的文章
L Zheng, CJ Kelly, SP Colgan - American Journal of Physiology-Cell Physiology, 2015